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Uveitis

(Macular Edema associated with non-infectious uveitis)

  • Uveitis is a collection of inflammatory conditions affecting the eye.
  • In the U.S. there are approximately 120 cases /100,000 adults. Most patients are aged 20-50 years.1 Overall the prognosis is good with appropriate treatment.
  • Uveitis does not cause mortality but morbidity results from chronic swelling in the retina (macular edema) that leads to damage to the structures of the eye, including the retina and the lens (cataracts) and complications from medications.
  • Macular edema may be found associated with any geographic location of uveitis and is the dominant cause of vision deterioration and potential vision loss in patients with uveitis2.

1Jennifer E. Thorne,  Eric Suhler,  Martha Skup  et  al,  JAMA  Ophthalmol. 2016;134(11):1237-1245. 2 Karim R, Sykakis E, Lightman S, Fraser-Bell S. Interventions for the treatment of uveitic macular edema: a systematic review and meta-analysis. Clin Ophthalmol 2013;7:1109-1144.

Retinal Vein Occlusion (RVO)

  • Retinal vein occlusion is blockage of the veins that drain the retina.
  • RVO is a common cause of vision loss, affecting 16 million people (5.20 per 1000) world wide.
  • It is the leading cause of blindness from retinal vascular disease after diabetic retinopathy.
  • RVO is most often caused by atherosclerosis and the formation of a blood clot. It can lead to further eye problems including glaucoma and macular edema.

Diabetic Macular Edema (DME)

  • Diabetic Macular Edema is an accumulation of fluid in the macula caused by leaky blood vessels as a consequence of diabetes mellitus.
  • It is defined as retinal thickening within 2 disc diameters of the macula center.
  • Diabetic retinopathy is a leading cause of new cases of legal blindness among working-age Americans and represents a leading cause of blindness in this age group worldwide.1
  • It may cause images to appear blurry or wavy and colors that seem “washed out”.

1 Klein BE. Overview of epidemiologic studies of diabetic retinopathy. Ophthalmic Epidemiol 2007;14:179-83.

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